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There are 45 twenty-letter words containing 2A, E, M, S and X

acetylhexosaminidaseAIDS-related␣complexesalarums␣and␣excursionsAlexander␣polynomialsaminoexotripeptidaseanatomical␣snuffboxesarylcyclohexylaminesa␣week␣from␣next␣Tuesdayblue␣book␣examinationscarboxamidoadenosinecarboxamidopeptidaseclinical␣examinationscompact␣executive␣carscyclomaltodextrinasedesacetoxywortmanninentrance␣examinationsexhausted␣combinationextracytoplasmicallyextra␣extra␣extra␣smallfactorial␣experimentsheptamethoxyflavoneshexamethyldisilanizehexamethyldisilazanehexamethyldisilizanehexamethyldisiloxaneimperial␣examinationsmanic␣pixie␣dream␣girlsMaximilian␣sunflowersmercaptocarboxylatesmetalloexopeptidasesmonocarboxypeptidaseneed␣one's␣head␣examinednumerical␣taxonomistsperformance␣anxietiesphysical␣examinationspremaxillary␣agenesispseudoapproximationsSouth␣American␣gray␣foxSouth␣American␣grey␣foxsphenomaxillary␣fossasulfamethoxypyrazinesulphamethoxydiazineuranium␣hexafluoridesValsalvian␣experimentvis␣medicatrix␣naturae

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 109 words
  • Spanish Wiktionary: 1 word
  • Italian Wiktionary: no word
  • German Wiktionary: 8 words
  • Portuguese Wiktionary: 2 words
  • Dutch Wiktionary: 27 words

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