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There are 688 twenty-one-letter words containing A, E, 2I and 2S

abdominohysterotomiesabstract␣expressionism Abstract␣Expressionismabstract␣expressionistaccelerating␣universesacetylglucosaminidaseacetylhexosaminidasesacute␣mountain␣sicknessadaptive␣immune␣systemsadenosinetriphosphate adenosine␣triphosphateadenotonsillectomizesadministrative␣regionsadmiral␣of␣the␣Swiss␣Navyadrenocorticosteroidsaffine␣transformationsafter␣all␣is␣said␣and␣doneagricultural␣densitiesairbreathing␣catfishesAldabra␣giant␣tortoisesalgebraic␣subvarietiesalgorithmic␣randomnessalphapapillomavirusesalternating␣series␣testalternative␣hypothesisalternative␣lifestylesAmerican␣cliff␣swallowsanchimeric␣assistancesanterior␣median␣fissureantiballistic␣missiles anti-ballistic␣missilesanticonfederationistsantideconstructionistantienvironmentalists anti-environmentalistsantimiscegenationistsantitranscendentalismAnton-Babinski␣syndromeappointments␣in␣Samarraarchitectural␣shinglesarctic␣ground␣squirrelsarguments␣from␣illusionarithmetic␣progressionArndt-Eistert␣synthesisarteriovenous␣fistulasarticles␣of␣associationas␣if␣there␣is␣no␣tomorrowAsk␣a␣Stupid␣Question␣Dayassistive␣technologiesasteroseismologicallyastronomical␣transientasymmetrical␣spinnakerattends␣to␣one's␣knittingauctorial␣descriptivesauriculares␣anterioresauriculares␣superioresaustausch␣coefficientsAustralian␣pratincolesAustralian␣white␣ibisesautonomous␣communitiesbackwards␣time␣machinesbad␣things␣come␣in␣threesballistic␣coefficientsBangka␣Belitung␣Islandsbarking␣dogs␣seldom␣bitebeats␣with␣the␣ugly␣stickbicameral␣legislaturesBillingsgate␣pheasantsbitches␣eating␣crackersbiting␣someone's␣head␣offblackish-gray␣antshrikeblack-striped␣wallabiesblew␣this␣popsicle␣standblow␣this␣popsicle␣stand blow␣this␣Popsicle␣standbonfires␣of␣the␣vanitiesbrass␣instrumentalistsBritish␣Virgin␣IslanderBrussels-Capital␣RegionBruton's␣tyrosine␣kinasebuilds␣castles␣in␣the␣airbulletin␣board␣servicesbuys␣straw␣hats␣in␣wintercabinets␣of␣curiositiesCalifornia-style␣pizzascarboxamidoadenosinescardiovascular␣diseaseCarolingian␣minusculescasualty␣of␣superioritycellooligosaccharidescentral␣processing␣unitcerebral␣localisationscertificates␣of␣depositChamisha␣Chumshei␣TorahChatham␣Islands␣penguinchemical␣sensitivitieschemoradiosensitiserschemoradiosensitivityChinese␣Communist␣Partychi-square␣distributionchitooligosaccharideschondroitinsulfataseschondroitinsulphataseChristian␣UniversalismChristmas␣caterpillarschronic␣wasting␣diseasecisheteropatriarchiesclassification␣schemesclassification␣societyCocos␣(Keeling)␣Islanderscognitive␣disabilitiescold␣agglutinin␣diseasecollaborationist␣statecollectivist␣anarchismcollectivist␣anarchist

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