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There are 281 twenty-one-letter words containing A, E, I, O, P, S and Y

(page 3)

spinoprezygapophysealspondyloarthropathiesstereomicroscopicallystorage␣polysaccharidesulfachloropyridazinesuperior␣thyroid␣arterysupernumerary␣rainbowssympathetic␣detonationsympathetic␣vibrationssyngenesiotransplantstelevision␣personalitytetrahydropyrimidinestheoretical␣physiciststhere's␣a␣lid␣for␣every␣potthiogalactopyranosidetriphenylchlorosilanetrypanosusceptibilitytwo␣ha'pennies␣for␣a␣pennytypewriter␣apostrophestypographic␣apostropheunemployment␣insuranceupper␣respiratory␣tractvideofluoroscopicallywalking␣corpse␣syndromewalking␣encyclopaediasWellhausen's␣hypothesiswhat␣is␣your␣phone␣numberwhitecoat␣hypertension white-coat␣hypertension white␣coat␣hypertensionwhite-gaped␣honeyeatersxenotransplantabilityyellow-edged␣pygarctiasyellow-rumped␣mannikinsyou␣must␣be␣fun␣at␣parties

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 231 words
  • Spanish Wiktionary: 1 word
  • Italian Wiktionary: no word
  • German Wiktionary: 19 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 12 words

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