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There are 31 twenty-one-letter words containing C, E, M, 3S and Y

acetylhexosaminidasesaminoacyltransferasesasteroseismologicallycarbamoyltransferasescardiovascular␣systemscentral␣nervous␣systemscholecystogastrostomydisjunctive␣syllogismsemphysematous␣cystitisenteric␣nervous␣systemsgalactosylceramidasesincident␣ticket␣systemsLyminster␣and␣CrossbushMendes␣da␣Costa␣syndromemucopolysaccharidasesmucopolysaccharidosesmuscle-eye-brain␣diseaseoak␣processionary␣mothsobsessive-compulsivitypachydermoperiostosisphosphoglyceromutasesSaint-Rémy-lès-Chevreusesecond␣impact␣syndromessecond-system␣syndromesseismic␣sustainabilityset␣one's␣watch␣by␣someoneShockley-Queisser␣limitsocial␣security␣numbersstriking␣someone's␣fancytactical␣assembly␣areasTwelve␣Days␣of␣Christmas

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 46 words
  • Spanish Wiktionary: no word
  • Italian Wiktionary: no word
  • German Wiktionary: 6 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 7 words

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