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There are 53 twenty-one-letter words containing D, E, 2F, R and S

afraid␣of␣one's␣own␣shadowbuffalobur␣nightshadesbuffaloburr␣nightshadebuff-breasted␣sandpipercertificates␣of␣depositdefensive␣indifferencedeflection␣differencesdifferential␣diagnosesdifferential␣diagnosisdifferential␣equationsdifferential␣operatorsdifferential␣structureEast␣African␣Federationfair-weather␣friendshipFalklands␣fritillariesfalls␣at␣the␣final␣hurdlefeed␣a␣cold,␣starve␣a␣feverFinnish␣forest␣reindeerfluorodesulfurizationfootloose␣and␣fancy␣freeforewarned␣is␣forearmedfortune␣favours␣the␣boldFriedel-Crafts␣reactionget␣one's␣affairs␣in␣orderget-out-of-jail-free␣cards get␣out␣of␣jail␣free␣cardshistodifferentiationslesser␣included␣offencelesser␣included␣offenselife␣and␣soul␣of␣the␣partymatters␣of␣life␣and␣deathmicrodifferentiationsofficious␣intermeddleroff␣like␣a␣bride's␣nightieone␣card␣shy␣of␣a␣full␣deckorange-footed␣scrubfowlPorter-Duff␣compositingpreemptive␣self-defencepride␣comes␣before␣a␣fallput␣one's␣affairs␣in␣orderright␣hand␣of␣fellowshipset␣one's␣affairs␣in␣orderSkeffington's␣daughterssoftware␣defined␣radiosSpofforth␣with␣Stockeldtalk␣the␣ears␣off␣a␣donkeyten␣points␣to␣Gryffindortransdifferentiationstrans-identified␣femaleVan␣de␣Graaff␣generatorswatched␣the␣feathers␣flyWoodward-Hoffmann␣rulesyellow-shafted␣flickers

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