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There are 27 twenty-one-letter words containing D, N, O, R, U and X

deoxyribonucleotidasedesoxyribonucleic␣aciddesoxyribonucleolyticdesoxyribonucleosidesdesoxyribonucleotidesdibutylhydroxytoluenedideoxyribonucleosidedideoxyribonucleotidedihydroxysuccinic␣aciddumber␣than␣a␣box␣of␣rocksEastern␣Orthodox␣Churchendodeoxyribonucleaseexodeoxyribonucleasesgovernment␣expenditurehydroxyanthraquinoneshydroxydeoxyguanosinehydroxynaphthoquinonehydroxyphenylpyruvateinternal␣carotid␣plexusLennox-Gastaut␣syndromemetaxylohydroquinonesparadoxical␣undressingproduction␣externalityRussian␣Orthodox␣ChurchSerbian␣Orthodox␣Churchsuxamethonium␣chlorideWitherspoon-excludable

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 83 words
  • Spanish Wiktionary: no word
  • Italian Wiktionary: no word
  • German Wiktionary: 4 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 11 words

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