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There are 74 sixteen-letter words containing 3D, 2E, I and S

acquired␣disorderaldehyde␣oxidasesbearded␣reedlingsbloodymindedness bloody-mindednessclosedmindedness closed-mindednessdead␣as␣ditch-waterdeadly␣nightshadedead␣tree␣editionsdehydrochloridesdehydropeptidasedeindividualizesdeindustrialiseddeindustrializeddendrerpetontidsdesert␣dandelionsdesignated␣driverdideoxyadenosinedihydroceramidesdiminished␣seconddipped␣headlightsdirect␣descendantdirected␣verdictsdisintermediateddisulfide␣bridgesdodecasaccharidedodecylmaltosidedoublemindedness double-mindednessdouble-sided␣dildoeating-disorderedforbidden␣degreesHardanger-fiddles Hardanger␣fiddleshexadecahedroidshooded␣tickspiderhorsehead␣fiddles horse-head␣fiddles horse␣head␣fiddlesicosidodecahedraimidodipeptidaseIndependence␣Dayslecithodendriidsmalondialdehydesmiddle-age␣spreadsmiddle␣infieldersmodel-based␣designplay␣second␣fiddlepseudodiadematidpseudodipeptidespseudodipeptidicpseudopimelodidspseudorandomisedpseudorandomizedpseudouridylatedpseudoxenodontidred-headed␣Eskimosred␣osier␣dogwoodsred-veined␣dartersregular␣dividendssemistandardizedside-straddle␣hopsspring-loaded␣modetendermindedness tender-mindednesstwisted␣and␣turnedunderdimensionedunderdisciplinedunderdistributedunderdiversified under-diversifiedupside␣down␣fridgeYoneda␣embeddings

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