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There are 32 sixteen-letter words containing 2D, E, F, R and 2S

Bakersfield␣soundbed-and-breakfasts bed␣and␣breakfastsdisc-tongued␣frogsdisease␣of␣despairdisregardfulnessdisulfide␣bridgesdwarf␣spheroidalsfederal␣districtsfinished␣productsfish␣odor␣syndromefloppy␣disc␣drivesfloppy␣disk␣drivesfood-borne␣diseasefriends␣of␣friendsheterodisulfideshorsehead␣fiddles horse-head␣fiddles horse␣head␣fiddlesmicrocaddisfliesmodes␣of␣discoursemodified␣starchespseudostratifiedrabid␣wolf␣spidersrises␣from␣the␣deadSandford-on-ThamesSandifer␣syndromeself-administeredsphincters␣of␣Oddiswords␣of␣Damoclesunderdiversifies under-diversifies

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