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There are 81 sixteen-letter words containing 2D, E, M, R and 2S

Andromeda␣strainsBasedow's␣syndromebridled␣titmousesCommander␣IslandsDa␣Costa's␣syndromedamsel␣in␣distressdeskside␣computerdiamond␣crossoverdiminished␣thirdsdiminished␣triadsdisintermediatesdispersive␣modelsDomesday␣circuitsdrives␣someone␣maddynamic␣IP␣addressendorhamnosidasefish␣odor␣syndromeGardner's␣syndromegood-humourednessgood-temperednesshard␣deterministslower␣middle␣classmad␣hatter␣diseasemeridiolestidansmicrocaddisfliesmiddle-age␣spreadsMiddle␣EasternersMiddle␣Easternismmidsummer␣daisiesmidsummer␣madnessmisunderstandersmisunderstandestmisunderstandethmisunderstandingmodes␣of␣discoursemodified␣starchesmurders␣by␣suicidenarrowmindedness narrow-mindedness narrow␣mindednessNjolstad␣syndromenodulisporamidesold␣as␣the␣Pyramidsold-timer's␣disease old-timers'␣disease old␣timer's␣disease old␣timers'␣diseasepremeditatednessprepared␣mustardspseudonormalisedpseudorandomisedpseudorandomizespseudorandomness pseudo-randomnesspseudoremaindersread␣someone's␣mindred-headed␣Eskimosrises␣from␣the␣deadSandford-on-ThamesSandifer␣syndromesecondary␣modernsself-administeredsemidreadnoughts semi-dreadnoughtssemistandardizedshaded-pole␣motorssmall␣dog␣syndromeSneddon's␣syndromeSouthern␣Midlandsspectrum␣disorderspiritual␣middensStendhal␣syndromestrongmindedness strong-mindednessswords␣of␣Damoclestendermindedness tender-mindednesstheridiosomatidsunderadjustmentsupper␣middle␣classvested␣remainders

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