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There are 58 sixteen-letter words containing 2D, 2I and 3S

addressabilitiesadiposis␣dolorosaardisicrenosidesassisted␣suicidesbisdigitoxosidesdaily␣disposablesdamsel␣in␣distressDanish␣West␣Indiesdefensive␣designsdeindustrialisesdiamond␣crossingsdigalactosidasesdiminished␣sixthsdisappointednessdiscoglossideansdiscospondylitisDiscovery␣Islandsdiscussing␣Ugandadisease␣of␣despairdisjointednessesdiskospondylitisdispersive␣modelsdissatisfiednessdistolasterosidedo␣as␣I␣say,␣not␣as␣I␣dodomestic␣disputesedible␣bird's␣nestshybrid␣disgenesishydrodissectionshydrodistensionsmidsummer␣daisiesmisdistinguishedMuddy␣Mississippiold-timer's␣disease old-timers'␣disease old␣timer's␣disease old␣timers'␣diseaseosteohydatidosispotassium␣iodidespseudanthessiidspseudodiffusionspseudodimensionspseudostigmatidsresiduary␣devisesroadside␣thistlessimplemindedness simple-mindednesssinglemindedness single-mindednessskinbound␣diseaseskirts␣and␣kidneyssolid-state␣drivesspondilodiskitisspondylodiscitisspondylodiskitisstandardisationssubdistinguishedundisestablished

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