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There are 51 twenty-one-letter words containing 2D, E, F, I, N and R

abdominocardiac␣reflexabsent-minded␣professoradditive␣manufacturingafraid␣of␣one's␣own␣shadowafter␣all␣is␣said␣and␣doneall␣the␣world␣and␣his␣wifeArlecdon␣and␣Frizingtonbuff-breasted␣sandpipercast␣one's␣net␣far␣and␣wideCity␣and␣County␣of␣Denverconducted␣interferencedance␣to␣a␣different␣tunedark␣as␣the␣inside␣of␣a␣cowdeepwater␣cardinalfishdefensive␣indifferencedeflection␣differencesdictionary␣definitionsdifferential␣diagnosesdifferential␣diagnosisdonor-specific␣antibodydrunk␣as␣a␣fiddler's␣bitchenantiodifferentiatederrors␣of␣the␣second␣kindfibrochondroinductivefiddled␣while␣Rome␣burntfiddles␣while␣Rome␣burnsfingers␣and␣toes␣crossedforewarned␣is␣forearmedgolden␣wonder␣killifishHighcliffe␣and␣Walkfordlesser␣included␣offencelesser␣included␣offensemarch␣to␣a␣different␣drummatters␣of␣life␣and␣deathnature-deficit␣disorder nature␣deficit␣disorderofficious␣intermeddlerPicard-Lindef␣theoremradio␣direction␣findersrose-crowned␣fruit-dovesself-deserting␣avoidantsilane-modified␣polymersoftware␣defined␣radiossurface-supplied␣divingSydney␣funnel-web␣spidertrans-identified␣femaleunsaturated␣fatty␣acidsurea-formaldehyde␣resinvirgin␣fields␣epidemicswomen␣and␣children␣firstYarnfield␣and␣Cold␣Meece

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