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There are 53 twenty-one-letter words containing 2D, E, M, O and 2S

absent-minded␣professorbarking␣dogs␣seldom␣bitebastard␣big-footed␣mousecarboxamidoadenosinescrossed␣ladders␣problemdanced␣on␣someone's␣gravedark␣crimson␣underwingsdarken␣someone's␣doorwaydatabase␣administratordeacetylmarsformosidedihydrosphingomyelinsdisembarkment␣syndromedisseminated␣sclerosisdominant␣seventh␣chordsDonaldson-Thomas␣theorydon't␣get␣someone␣starteddose␣of␣one's␣own␣medicineDr.␣Strangelove␣syndromeduodenoduodenostomiesEddington␣luminositiesEhlers-Danlos␣syndromesendogalactosaminidasefiddles␣while␣Rome␣burnsfield␣emission␣displaysgross␣domestic␣productshand␣someone␣their␣cardshardened␣someone's␣heartill␣doers␣are␣ill␣deemerskicked␣ass␣and␣took␣namesKöhlmeier-Degos␣diseaseleaves␣much␣to␣be␣desiredmade␣someone's␣blood␣boilMalecite-PassamaquoddyMaliseet-Passamaquoddy Maliseet–Passamaquoddymeadow␣grass␣dermatitisMendes␣da␣Costa␣syndromemetalloendopeptidasesmonodehydroascorbatesnonsense-mediated␣decayparade␣passed␣someone␣bypressure␣makes␣diamondspseudohermaphroditismpseudomonosaccharidespseudosclerodermatousscrambled␣egg␣slime␣moldsecondary␣modern␣schoolsecond␣impact␣syndromessecond-system␣syndromessliding␣filament␣modelssternocleidomastoideiwho␣died␣and␣made␣you␣bosswrapped␣one's␣arms␣around

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