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There are 64 twenty-one-letter words containing 2D, L, 2O and 2S

alkylhydroperoxidasesbarking␣dogs␣seldom␣bitebet␣dollars␣to␣doughnutsblack-hooded␣antshrikeschlorodeoxyadenosinescolored␣inside␣the␣linesCopeland-Erdős␣constantCotswold␣morris␣dancingcould␣not␣have␣cared␣lesscrooked␣as␣a␣dog's␣hind␣legcrossed␣ladders␣problemcyclodeoxynucleosidesdeacetylmarsformosidedesoxyribonucleosidesdesoxyribonucleotidesdigital␣pre-distortionsdihydrosphingomyelinsdishonorable␣dischargedo␣a␣land-office␣businessdolichyldiphosphataseDonaldson-Thomas␣theoryDr.␣Strangelove␣syndromeDutton␣World␣SpeedwordsEddington␣luminositiesEhlers-Danlos␣syndromesendogalactosaminidaseendotransglycosidasesEurasian␣collared␣dovesfought␣like␣cats␣and␣dogsgentiobiosylodorosideHeads␣of␣the␣Valleys␣Roadhow␣do␣you␣spell␣this␣wordhydrodesulphurisationhydrogen␣gas␣electrodeshydroxyethylrutosideshydroxyprostaglandinsKöhlmeier-Degos␣diseaseleaves␣a␣lot␣to␣be␣desiredlipodepsinonapeptidesmade␣someone's␣blood␣boilmetalloendopeptidasesosteochondrodysplasiaosteochondrodysplasicphosphatidylinositidephysiologic␣dead␣spacesPolish␣Lowland␣Sheepdogpreferred␣stockholderspseudoachondroplasticpseudooligosaccharidepseudosclerodermatousRoss-Littlewood␣paradoxsecondary␣modern␣schoolslot-loading␣disc␣drivessocial␣anxiety␣disorderstand␣on␣the␣shoulders␣ofstand␣out␣like␣dog's␣ballsstand␣up␣on␣one's␣hind␣legssternocleidomastoideistood␣out␣like␣dog's␣ballsteardrop␣tubeshoulderstool-assisted␣speedrunstwo-spotted␣scoliid␣waspuniversal␣product␣codesvoluntary␣aided␣schools

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