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There are 85 twenty-one-letter words containing D, E, F, 2O and 2S

absent-minded␣professorafraid␣of␣one's␣own␣shadowanticonfederationistsbastard␣big-footed␣mousebiting␣someone's␣head␣offbitten␣someone's␣head␣offcertificates␣of␣depositchondroitinsulfatasesconfessional␣debuggingcourt␣of␣second␣instancecurse␣of␣dimensionalitycystofilobasidiaceousdark␣as␣the␣inside␣of␣a␣cowdeacetylmarsformosidedeconfessionalisationdeconfessionalizationdefect␣of␣one's␣qualitiesdeprofessionalizationdesulfoglucosinolatesdiphosphotransferasesdo␣a␣land-office␣businessdose␣of␣one's␣own␣medicineEast␣Riding␣of␣Yorkshireerrors␣of␣the␣second␣kindfalse␣saber-toothed␣catsfalse␣sabre-toothed␣catsfetal␣alcohol␣syndromesfingers␣and␣toes␣crossedFirst␣New␣England␣Schoolflexible␣sigmoidoscopyforeign␣correspondentsfought␣like␣cats␣and␣dogsFrench␣and␣Iroquois␣WarsFrobenius␣endomorphismfructoligosaccharidesget␣off␣of␣someone's␣cloudget␣one's␣affairs␣in␣ordergrandmother's␣footstepshaberdasher␣of␣pronounsHeads␣of␣the␣Valleys␣Roadhistodifferentiationshouses␣of␣accommodationin␣every␣sense␣of␣the␣wordjump␣before␣one␣is␣pushedlong␣run␣for␣a␣short␣slidemakes␣the␣best␣of␣a␣bad␣jobMaster␣John␣Goodfellowsministries␣of␣educationmonofixation␣syndromesNorfolk␣Island␣star␣pinenot␣do␣someone␣any␣favorspenny␣wise,␣pound␣foolishpersonal␣defense␣weaponpostperfusion␣syndromepotassium␣ferrocyanidepoverty␣is␣a␣state␣of␣mindpreferred␣stockholderspseudologia␣fantasticaput␣one's␣affairs␣in␣orderreformulated␣gasolinesrequests␣for␣productionrose-crowned␣fruit-dovesrufous-backed␣antvireosrufous-collared␣sparrowSanta␣Fe␣Island␣tortoisesee␣the␣wood␣for␣the␣treessends␣to␣the␣glue␣factoryset␣one's␣affairs␣in␣ordershoulder-of-mutton␣sailssoftware␣defined␣radiossold␣freezers␣to␣EskimosSpofforth␣with␣Stockeldstand␣on␣one's␣own␣two␣feetstand␣on␣the␣shoulders␣ofstormed␣out␣of␣the␣blockssulfur-crested␣cockatooSunday␣of␣the␣Five␣Loavessuspension␣of␣disbelieftake␣someone's␣word␣for␣ittaking␣someone's␣head␣offtragedies␣of␣the␣commonstransport␣safety␣boardstwo␣sides␣of␣the␣same␣coinWest␣Riding␣of␣Yorkshireyouthful␣indiscretions

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