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There are 272 eighteen-letter words containing E, P, S and 2U

alphabaculovirusesamplexus␣reservatusanonymous␣sculptureanticrepuscular␣rayauriculotherapistsautomorphic␣numbersballistic␣pendulumsBatson␣venous␣plexusbrush-tailed␣penguinbrush-tailed␣possumsbrute␣for␣punishmentburden␣of␣persuasionbuttoning␣up␣one's␣lipbuying␣temperaturescapsuloligamentouscast␣up␣one's␣accountschucked␣up␣the␣spongeChukotski␣Peninsulaclosure␣temperaturecompulsory␣purchasecomputer␣simulationcomputing␣languagesconsecutio␣temporumcounterdeputationscounterpunishmentscreeping␣buttercupscute␣as␣a␣speckled␣pupdependency␣culturesdesupersaturationsdiesel␣multiple␣unitdispute␣resolutionsdon't␣get␣your␣hopes␣upduck-billed␣platypusDupuytren's␣fracturedustpans␣and␣brushesencephalopuncturesEsopus␣Spitzenburgsethylsulphuric␣acidEuropean␣Portugueseeustreptospondylusexecutive␣producersexperimentum␣crucisexploding␣cucumbersfibrinosuppurativeflying␣saucer␣groupsfuture␣progressivesGalician-Portugueseglomerular␣capsulesGunn-Peterson␣troughhanging␣up␣one's␣spursheap␣insult␣on␣injuryhyperaccumulationshyperfine␣structureignotum␣per␣ignotiusimmunosupernatantsimmunosuppressantsimmunosuppressionsimmunosuppressivesimmunotherapeuticsinductive␣couplingsinput-output␣sectioniron-sulfur␣proteinsiron-sulphur␣clusteriron-sulphur␣proteinjumped␣through␣hoopsjuniper␣bush␣katydidjurisprudentialistkeeps␣one's␣mouth␣shutlabium␣superius␣orisleucocoprineaceouslumpenbourgeoisiesmeadow␣jumping␣mousemedium␣spiny␣neuronsmember␣of␣upper␣housemercury-vapour␣lampsminisupercomputersminisupercomputingmolecular␣compoundsmultineurotrophinsmultiquasiparticlemusculoaponeuroticneighbouring␣groupsnonsuperconductingnonsuperconductorsnonsupernaturalistnuclear-pulse␣rocketObergruppenführerson-base␣plus␣sluggingorthopneumovirusesouter␣automorphismsoverscrupulousnesspachypleurosauridsp-adic␣absolute␣valuePaisley␣Undergroundparainfluenzavirusparticular␣churches particular␣Churchespaucituberculatansperfluorosulfonateperiodic␣structuresphosphoglucomutasepilosebaceous␣unitspitted␣tubeshoulderpleurolophocercouspluck␣up␣one's␣courageplusquamperfectionpneumomediastinumspneumotherapeuticspolyunsaturated␣fatpoor␣as␣a␣church␣mousePortuguese␣man-of-warPortuguese␣men-of-warPortuguese␣pavementPortuguese␣RepublicPortuguese␣SheepdogPortuguese␣Water␣DogPortuguesificationpotassium␣gluconatepotassium␣guanylatepot␣scrubber␣brushespoured␣one's␣heart␣outpoured␣out␣one's␣heartpreagriculturalistpresent␣subjunctiveproscenium␣curtainsProto-South␣Sulawesipseudoarticulationpseudobulbar␣affectpseudodiverticularpseudodiverticulumpseudoenthusiasticpseudoequalitarianpseudofluorescencepseudofolliculitispseudoguaianolidespseudoheterozygous

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