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There are 571 twenty-one-letter words containing 4E and S

absolutes␣of␣enfleurageaccelerating␣universesacetylcholinesterasesagreements␣in␣principleAlexander␣horned␣spherealternate␣reality␣gamesalternating␣series␣testalternative␣hypothesesalternative␣investmentalternative␣lifestylesannual␣general␣meetingsanterior␣scalene␣muscleArchimedean␣propertiesarse␣like␣a␣Japanese␣flagarseniuretted␣hydrogenartificially␣sweetenedas␣ever␣trod␣shoe-leather as␣ever␣trod␣shoe␣leatheras␣far␣as␣the␣eye␣could␣seeat␣Her␣Majesty's␣pleasurebar-breasted␣honeyeaterBasset␣Fauve␣de␣Bretagnebatted␣for␣the␣other␣sidebeen␣one's␣own␣worst␣enemyBehrens-Fisher␣problemsbelemnite␣battlefieldsbenzenedicarboxylatesbenzylphenethylaminesbetween-seasons␣jacketsbitten␣someone's␣head␣offblue-bellied␣black␣snakeblue-breasted␣fairywrenblue␣creeping␣gromwellsbread-and-butter␣lettersbreaking␣someone's␣heartbreathe␣one's␣last␣breathbrown␣envelope␣syndromebuckminsterfullerenesbus␣replacement␣servicebutterflies␣upon␣a␣wheelbutterflies␣upon␣wheelsCalifornia␣pepper␣treescall␣them␣as␣one␣sees␣themcandlestick␣telephonescast␣pearls␣before␣swinecell-adhesion␣molecules cell␣adhesion␣moleculescensus-designated␣placecerebrovasculogenesischanged␣like␣the␣seasonschanges␣like␣the␣seasonsChinese␣patent␣medicineChinese␣strawberry␣treeChinese␣water␣chestnutschondroskeletogenesisClaisen␣rearrangementsclosed␣feedwater␣heatercognitive␣estrangementcolored␣inside␣the␣linescommissions␣de␣bene␣essecompetitive␣tenderingsconservative␣extensionconservative␣treatmentconvertible␣securitiescooperative␣federalismcountercountermeasure counter-countermeasure counter-counter-measureCounter-Enlightenmentscredit␣where␣credit's␣duecyclohexadepsipeptidecysteinyl␣leukotrienesdanced␣on␣someone's␣gravedances␣of␣the␣seven␣veils Dances␣of␣the␣Seven␣Veilsdances␣on␣someone's␣gravedead␣men␣can␣tell␣no␣talesdeadnettle␣leaf␣beetlesdefect␣of␣one's␣qualitiesdefensive␣indifferencedeflection␣differencesDejerine-Sottas␣diseasedemonstrative␣legaciesdermatovenereologistsdescriptive␣adjectivesdescriptive␣geometriesdestroyer␣minesweepersdevil␣lies␣in␣the␣detailsdie␣just␣the␣way␣one␣liveddimethylphenanthrenesdips␣one's␣toe␣in␣the␣waterdon't␣get␣someone␣starteddon't␣let␣the␣bedbugs␣bitedon't␣shoot␣the␣messengerdose␣of␣one's␣own␣medicinedrive␣someone␣up␣the␣walldropped␣a␣dime␣on␣someonedrove␣someone␣up␣the␣wallDuke␣of␣Exeter's␣daughtereastern␣imperial␣eagleseastern␣Orphean␣warblerEast␣European␣Shepherdseasy␣peasy␣lemon␣squeezyeats,␣breathes,␣and␣sleepsechochemiluminescenceechoencephalographiesectophosphodiesterase

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