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There are 142 twelve-letter words containing E, I, 2M, S and Y

aerodynamismamidomethylsaminomethylsammonialyaseantisymmetryasymmetricalaxiom␣systemsaxisymmetric axi-symmetricbambermycinsbisymmetrieschamaemyiidscommensalitycommissivelycyber-Muslimsdemipyramidsdesymmetrizedissymmetricdynamimetersdysgerminomaembryotomiesemphysematicepimysiotomyepitympanumsetymologismsfiery␣skimmergymnodiminesgymnospermicgynemimeticsgynostemiumshappy␣mediumshemadynamicshemihomonymshemisymptomshemisyndromehemodynamicshomodynamieshydroskimmerhymenotomieshypomelanismimmeasurablyimmune␣systemimmunosystemintersymptomisosymmetricJimmy␣RiddlesJimmy␣WoodserLima␣syndromelimbic␣systemlymphotomiesMacGyverismsmegaministrymemory␣quiltsmemory␣sticksme,␣myself␣and␣ImeniscectomymeniscometrymercenaryismMercury␣dimesmerrymakingsmesmericallymesomyariansmesomyodiansmesosystemicmesotympanicmetadynamicsmetamysticalmetapsychismmetasystemicmetempsychicmethylaminesmethylsodiummetric␣systemmicromycetesmicropygmiesmicrosystemsMidsummer␣DaymillesimallyMinsky␣momentmise␣en␣abymesmisemployingmismethylatemolly␣millersmoney-makingsmonosystemicmultienzymesmuseumifyingmycogenomicsmyelolipomasmyelomatosismyofilamentsmyohaematinsmyomectomiesmyriagrammesmyringotomesmyristematicmyrmecobiidsmyrmeleonidsmysterianismnamby-pambiesninnyhammersnonsymmetricnymphotomiesOlympic␣Gamesosteomimicrypersymmetricplatycnemismpolydemonismpraseodymiumsecurity␣momssemiautonomysemidormancysemiformallysemihomologysemimaturitysemimilitary semi-militarysemimonopolysemimysticalsemimythicalseminormalcysemirandomlyseroimmunityshimmeringlysimple␣myopiaskimmity-ridesoy␣milk␣makerspit␣the␣dummystammeringlysymmetallismsymmetricalssymmetriciansymmetricitysymmetrifiedsymmetrisingsymmetrizerssymmetrizingsymptomatizesystematismsthymectomiesyummy␣mummieszymosimeters

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