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There are 143 twelve-letter words containing E, L, 2M and 2S

air␣embolismsalarm␣systemsallosemitismalmost␣primesassembly␣roombimetallismsblemishmentsblue␣skimmersclammishnessclam␣smackerscometesimalscomma␣splicescommensalismcommensalistcommercelesscommissivelycommunalisescosemisimplecyber-Muslimsdemuslimizes de-Muslimizesemblematisesemblematistsemblossomingetymologismsfat␣embolismsformal␣systemgemmologistshaemoplasmashammer␣blastshammerscalesHellstromismhelmsmanshiphommes␣fatalshomoplasmiesimmobilisersimmortalisesimmortalnessimperialismslimbic␣systemmacrosamplesMaglemoseansMaglemosiansmakes␣a␣musclematerialismsmaternalismsMcEllistrimsmedievalismsmegamusicalsmegaplasmidsmelanospermsmembranelessmemorialisesmemorialistsmeristemlessMermelsteinsmesmerisablemesoclimatesmesodermlessmesolimnionsMessalianismmetal␣mastersMichaelmasesmicrosamplesmiddle␣stumpsmilliosmolesmillisiemensmineralomassmisassembledmisassemblesmiserabilismmissemblancemissile␣farmsmolar␣mashersMolson␣musclemomentumlessmonumentlessmoral␣systemsmulberry␣massmulga␣madnessmultimerisesmultimessagemultistreamsmumblenewsesmurmurlesslymuscle␣morphsmuseumobilesmushroomlessMuslimloversMuslimphobesmyelomatosesmyelomatosisomnishamblespampelmoesespampelmoosespampelmousesplasmalemmasplasmodesmalplasmodesmaspolymersomespommel␣horsespompelmoosespompelmousespsalm-smiterspsammophilespseudomuslim pseudo-Muslimrummage␣salessarcolemmousscramblesomesemimysticalserial␣commasSimmentalerssimple␣metersSimple␣Simonsskimmed␣milkssmallest␣roomsmell-o-meterssmile-smirkedsmoked␣salmonsmooth␣musclesolemn␣massesSommerfeldtsSommervillessomnambulisesperm-blossom sperm␣blossomstem␣familiessummarisablesummercastle summer-castleSummerfieldssummerlinesssummersaultssummer␣schoolSummersvilleSummervillesswell-mobsmanswell-mobsmensymmetallismsymmetricalstemporalismstemsirolimus

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