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There are 394 sixteen-letter words containing E, M, 2S, T and Y

(page 3)

stenospermocarpystereomicroscopysterigmatocystinStickler␣syndromeSt␣Michael's␣on␣Wyrestone␣man␣syndromestrychnosperminestylohyoid␣musclesubsegmentectomysubstoichiometrysummary␣judgmentssupermasculinitysupermonstrouslysuperpromiscuitysupersymmetricalsupersymmetrizedsuprasegmentallysymmetricalitiessympathectomisedsympathectomizessympathomimeticssympathy␣verdictssymplectic␣groupssymplectisationssymplectizationssymptomatologiessynaptoneurosomesynsedimentarilysyntactocentrismsyntagmatarchiessystematisationssystematizationssystematologicalsystems␣languagestaxonomic␣systemstechnoecosystemsthermochemolysisthermohydrolysisthe␣sky␣is␣the␣limitthirtysomethings thirty-somethingsthree-party␣systemthymoproteasomesthyroidectomisesTivetshall␣St␣Marytrademark␣symbolstranscarbamylasetransfer␣paymentstreeman␣syndromestripartite␣systemtriple␣star␣systemtrypanosomacidestrypanosomicidestwentysomethings twenty-somethingstympanosclerosisunimpressibilityunmysteriousnessunpresumptuouslyunsystematicallyunsystematic␣riskunsystematizablevery␣low␣mass␣starsvestibular␣systemviscoelastometryvoluntary␣muscleswears␣too␣many␣hatsWestminster␣AbbeyYankee␣tunesmithsyuppie␣food␣stampszygomatic␣process

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 595 words
  • Spanish Wiktionary: 17 words
  • Italian Wiktionary: no word
  • German Wiktionary: 152 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 104 words

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