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There are 423 sixteen-letter words containing E, O, 2S and 2U

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supercutaneouslysuperferociouslysuperfluorescentsuperhaplogroupssuperhomogeneoussuperindustrioussuperinjunctions super-injunctions super␣injunctionssuperinstitutionsupermacroporoussupermastergroupsupermodulationssupermonstrouslysupernucleosomalsuperpopulationssuperprestigioussuperpromiscuitysuperpromiscuoussuperresolutionssupersaturationssuperstimulationsupersuppressionsupersynchronoussupervacaneouslysuppositiousnesssupracoracoideussupraligamentoussupranucleosomalsurface-to-surfacesurge␣suppressorssurmountablenesssurviving␣spousessuspense␣accountssuspension␣traumaSusquehanna␣Depotsweat␣one's␣guts␣outtechnostructuresten␣pound␣touriststerminus␣post␣quemtranscutaneouslytranspicuousnesstuberculisationstuberculostaticstubuloneogenesistulostomataceousturncurtovirusesturned␣up␣one's␣noseturn␣in␣successionturns␣of␣centuriesturquoiseberriestyrannosaurus␣rex Tyrannosaurus␣rex Tyrannosaurus␣Rexultraprestigiousultrasonosurgeryunaccustomednessunauspiciousnessunauthorizednessunburdensomenessuncensoriousnessunchivalrousnessuncompoundednessuncompulsivenessunconcludingnessunconclusivenessunconfoundednessuncourageousnessundocumentednessuneuphoniousnessunfastidiousnessunfavourablenessunfelicitousnessunharmoniousnessuninfectiousnessunmeticulousnessunmysteriousnessunobsequiousnessunobstructednessunostentatiouslyunpresumptuouslyunproductivenessunpropitiousnessunprosperousnessunpurposefulnessunquestionednessunrebelliousnessunremorsefulnessunscrupulousnessunsolicitousnessunsupportivenessunsuspiciousnessunthoughtfulnessvesiculopustularviruliferousnessviscerocutaneousvoluntary␣musclesvoluptuousnesseswalrus␣moustacheswash␣one's␣mouth␣outwash␣out␣one's␣mouthwhat␣would␣Jesus␣doyou␣snooze␣you␣loseyucks␣someone's␣yum

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