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There are 33 twenty-one-letter words containing 4E, S and X

Alexander␣horned␣spherebenzenedicarboxylatesconservative␣extensioncyclohexadepsipeptideDuke␣of␣Exeter's␣daughterendodeoxyribonucleaseepoxyeicosapentaenoicexecutive␣ball␣clickers Executive␣Ball␣Clickersexecutive␣ego␣functionsexodeoxyribonucleasesexplosive␣cyclogenesesexplosive␣cyclogenesisexternal␣iliac␣arteriesexternal␣oblique␣muscleextinction␣level␣eventsextra␣extra␣extra␣largesFrankenstein␣complexesgirlfriend␣experiencesheterogeneous␣mixtureshexamethylenediamineslexical␣correspondenceMaxwell␣Street␣Polishesmethylenedioxyphenylsreactive␣oxygen␣speciesreverse␣hyperextensionrunning␣for␣the␣exerciseserdexmethylphenidatesmart-reference␣proxiestakes␣it␣to␣the␣next␣levelthree␣marks␣of␣existenceturtle␣excluder␣deviceswhen␣one␣least␣expects␣it

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 187 words
  • Spanish Wiktionary: no word
  • Italian Wiktionary: no word
  • German Wiktionary: 33 words
  • Portuguese Wiktionary: 1 word
  • Dutch Wiktionary: 11 words

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