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There are 250 twenty-one-letter words containing 2E, F, R and 2S

absent-minded␣professorabsolutes␣of␣enfleurageaccessary␣after␣the␣factaccessory␣after␣the␣factafter␣all␣is␣said␣and␣doneairbreathing␣catfishesall␣that␣one's␣life's␣worthalternative␣lifestylesaminoacyltransferasesanterior␣median␣fissureanticonfederationistsarabinosyltransferasearse␣like␣a␣Japanese␣flagarteriovenous␣fistulasarylsulfotransferasesarylsulphotransferaseas␣far␣as␣the␣eye␣could␣seeas␣if␣there␣is␣no␣tomorrowautonomous␣prefecturesBasset␣Fauve␣de␣Bretagnebastard␣big-footed␣mouseBehrens-Fisher␣problemsbonfires␣of␣the␣vanitiesbrevity␣is␣the␣soul␣of␣witbuckminsterfullerenesbuff-breasted␣sandpiperbutterflies␣upon␣wheelscabinets␣of␣curiositiescarbamoyltransferasescast␣one's␣net␣far␣and␣widecast␣pearls␣before␣swinecertificates␣of␣depositcolour␣of␣someone's␣moneycome␣up␣smelling␣of␣rosescomfortable␣in␣one's␣skinconspiracies␣of␣silencecontinental␣breakfastscourt␣of␣second␣instancecurse␣of␣dimensionalitycytidylyltransferasesdark␣as␣the␣inside␣of␣a␣cowdeacetylmarsformosidedeprofessionalizationdifferential␣diagnosesdifferential␣diagnosisdiphosphotransferasesduress␣of␣circumstancesEast␣Riding␣of␣YorkshireEinstein␣refrigeratorsembarrassment␣of␣richesEmpire␣State␣of␣the␣Southequipotential␣surfaceserrors␣of␣the␣second␣kindescutcheons␣of␣pretenceFallen␣Jerusalem␣Islandfalse␣saber-toothed␣catsfalse␣sabre-toothed␣catsfarm␣business␣tenanciesfarnesylpyrophosphateferroelectric␣crystalsferroelectric␣shuttersfetal␣alcohol␣syndromesfiddles␣while␣Rome␣burnsFile␣Transfer␣Protocolsfine-needle␣aspirationsfine-structure␣constant fine␣structure␣constantfingers␣and␣toes␣crossedFinnish␣forest␣reindeerfirm␣hands␣at␣the␣tillersfirm␣hands␣on␣the␣tillersfirst␣angle␣projectionsfirst-chance␣exceptionsfirst␣cosmic␣velocitiesFirst␣New␣England␣SchoolFischer-Tropsch␣processfor␣all␣intense␣purposesforeign␣correspondentsformiminotransferasesfor␣the␣land's␣sakes␣aliveforum␣selection␣clausesFrankenstein␣complexesFrankenstein's␣monstersfreshwater␣pearl␣musselFrobenius␣endomorphismfrom␣where␣one␣is␣sittingfructosyltransferasesfuck␣someone's␣brains␣outfull␣English␣breakfastsgalactosyltransferasegeneral␣classificationget␣one's␣affairs␣in␣orderglucanosyltransferaseglucoronyltransferaseglucose-fructose␣syrupsglucuronyltransferasegoes␣off␣the␣reservationgrandmother's␣footstepsgreat␣brown␣kingfishersgreatest␣common␣factorsgroup␣specific␣antigensguest␣relation␣officershaberdasher␣of␣pronounsHeads␣of␣the␣Valleys␣RoadhistodifferentiationsHolstein-Lewis␣fracturehyperfibrinogenolysisimperfect␣subjunctives

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