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There are 43 words containing E, I, R, S and 2X

prix␣fixes  ——  antivaxxers anti-vaxxerscrux␣simplexexecutrixesxeroxcopies xerox␣copies  ——  matrix␣mixersperoxidoxinssix-yard␣boxesvortex␣mixersxylodextrins  ——  coexecutrixesexecutrixshipoxohydroxidesoxyhydroxidesxerox␣machines  ——  executrixshipsperoxiredoxinsperoxyredoxinssexual␣anorexiasexual␣anorexicsurgerymaxxing  ——  Coxeter␣matrixessexual␣anorexics  ——  deoxypyridoxinesextraperoxisomalhydroxyperoxidesperoxidoredoxinssexually␣anorexic  ——  bithorax␣complexeshydroxyperoxidasehydroxytamoxifens  ——  hydroxyperoxidases  ——  box-to-box␣midfieldersexocarboxypeptidasehexacarboxylic␣acidsout-of-box␣experiences  ——  exocarboxypeptidasesexodeoxyribonucleasehydroxythioxanthones  ——  exodeoxyribonucleaseshydroxydeoxyguanosine

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See this list for:

  • Scrabble in English: 3 words
  • French Wiktionary: 80 words
  • Spanish Wiktionary: no word
  • Italian Wiktionary: no word
  • German Wiktionary: 7 words
  • Portuguese Wiktionary: 8 words
  • Dutch Wiktionary: 1 word

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