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There are 43 sixteen-letter words containing 4E, 2S and Y

bat␣one's␣eyelashesbutterfly␣sleevescatch␣someone's␣eyeChinese␣cypressescomes␣up␣snake␣eyesdefense␣attorneysdeoxyketohexosesdesmethylsteranedestroyer␣leaderseight-legged␣essayelectrosyntheseseleemosynarinessemergency␣escapesErlenmeyer␣flaskserysenegalenseinexercise␣bicyclesfeasting␣one's␣eyesfeasts␣for␣the␣eyesGenovese␣syndromeheavyheartedness heavy-heartednessHennebique␣systemkeep␣one's␣eyes␣openkept␣one's␣eyes␣openkeyhole␣surgerieslesser␣grey␣shrikelesser␣yellowlegslifestyle␣diseaseMénière's␣syndromemonastery␣cheesesopen␣someone's␣eyesPeyronie's␣diseaseprehypertensivesQueensberry␣rulesRoyal␣Free␣diseasesequence␣assemblySeven␣Sleepers'␣Dayslippery␣sequencesuperheterodynessuperselectivelythose␣were␣the␣daysWestley␣Waterlesswith␣one's␣eyes␣open

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 151 words
  • Spanish Wiktionary: 2 words
  • Italian Wiktionary: no word
  • German Wiktionary: 18 words
  • Portuguese Wiktionary: 1 word
  • Dutch Wiktionary: 49 words

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