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There are 27 sixteen-letter words containing 3E, F, 2M and O

center␣of␣symmetrycentre␣of␣symmetrycommon␣differencedextroamfetamineeconomic␣freedomsfalse␣plum␣anemonefragmentectomieshomofermentativeimplementiferouskannemeyeriiformletters␣of␣commentmake␣mileage␣out␣ofmake␣the␣first␣moveman-to-man␣defensesmaster␣of␣one's␣timemedium␣of␣exchangememo␣for␣the␣recordmetaformaldehydemethylkaempferolmicrofadeometersmoments␣of␣silenceMoneymaker␣effectrefreshment␣roomsself-improvementssemifermentationterm␣of␣endearmentthe␣measure␣of␣a␣man

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