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There are 58 sixteen-letter words containing 3E, F, M and 2S

at␣the␣best␣of␣timesBeast␣from␣the␣Eastchemical␣defensescomedies␣of␣errorsdefense␣mechanismdesferrioxamineseconomies␣of␣scaleeffranchisementsembryofetoscopesenfranchisementsErlenmeyer␣flaskseumusae␣leaf␣spotsfeeblemindedness feeble-mindednessfeel␣someone's␣painfermentativenessflehmen␣responsesfreedom␣of␣the␣seasfrom␣where␣one␣sitsgives␣someone␣fiveglasses␣of␣welcomehouses␣of␣easementhousewife's␣eczemaimperfectivenessman-to-man␣defensesmaster␣of␣one's␣timemaster␣of␣the␣horseMasters␣of␣Sciencemeaningfulnessesmoments␣of␣silencemoney␣of␣necessityMössbauer␣effectsmultifacetednessolefin␣metathesisperfectissimatesperformativenessplay␣someone␣falserefreshment␣roomsresistance␣framesrise␣from␣the␣ashesrises␣from␣the␣deadsave␣someone's␣faceschemes␣of␣studiesseal␣someone's␣fateself-administeredself-chastisementself-confinementsself-deterministsself-improvementssemidefinitenessshamefacednessesstools␣of␣easementstreet␣performerssupreme␣sacrificetake␣someone's␣lifeunremorsefulnessunshamefacednessvestimentiferans

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