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There are 55 sixteen-letter words containing 2E, F, I, 2S and Y

Abernethy's␣fasciaaquiferous␣systembeneficiaryshipsbusiness-friendlychild␣safety␣seatscyberfriendshipsecclesiastifyingexcuse␣my␣francais excuse␣my␣Francais excuse␣my␣françaisfamily␣businessesfarnesylcysteinefeasting␣one's␣eyesFleury-les-Aubraisflying␣buttressesforestry␣machinesfornicate␣gyrusesfrisk␣someone's␣clygay␣panic␣defensesglycodiversifieshydrogensulfites hydrogen␣sulfiteshyperforeignismslifestyle␣diseasemoney␣of␣necessityoffensensitivityon␣the␣shady␣side␣ofpair␣of␣eyeglassespass␣the␣time␣of␣dayperoxydisulfatesphase-shift␣keying phase␣shift␣keyingphenylsulfamidesplays␣with␣oneselfreferendaryshipsreflectionlesslyRoyal␣Free␣diseasesafety-deposit␣boxSandifer␣syndromesecurity␣officersselfconsistentlyself-sufficientlyself-synchronizedself-synchronizessemisuccessfullysight␣for␣sore␣eyessocial␣safety␣netsspeech␣disfluencysuperb␣fairywrenssuperdiffusivelysuperferociouslytransesterifyingwireless␣fidelityworks␣of␣necessityyellow␣fat␣disease

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 73 words
  • Spanish Wiktionary: no word
  • Italian Wiktionary: no word
  • German Wiktionary: 5 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 16 words

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