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There are 85 sixteen-letter words containing 2E, M, 3S and Y

antisymmetrisersaquiferous␣systemAssisi␣embroideryasteroseismologyasymmetricalnessBasedow's␣syndromechemosystematicscomes␣up␣snake␣eyescompressed␣yeastscyberpessimisticdesmethylsterolsdigestive␣systemsdisassembly␣linesdouble␣star␣systemdynamic␣pressuresdysembryogenesisdyshematopoiesisdysmorphogenesiselectoral␣systemseleemosynarinessendocrine␣systemsextrasolar␣systemfamily␣businessesfrisk␣someone's␣clygreat␣martyressesHaversian␣systemshemihypesthesiashouses␣of␣assembly Houses␣of␣Assemblyhypermassivenesshysteresis␣motorsinner␣Solar␣SystemLadies␣Mayoresseslumpy␣skin␣diseaselymphatic␣vesselsmalonylesterasesmass␣spectrometrymechanosynthesismetabiosynthesismetempsychosistsmetempsychosizesmiliary␣abscessesmonastery␣cheesesmyelosuppressantmyelosuppressingmyelosuppressionmyelosuppressivemysteriousnessesnetwork␣subsystemnonsense␣syndromeopen␣someone's␣eyesoperating␣systemsouter␣Solar␣Systemoversystematisedoversystematisesoversystematizespalaeoecosystemsplanetary␣systemsprymnesiovirusespseudoisoenzymespseudonymousnesspseudosymmetriespyrosomal␣diseasesemantic␣analysessemipersistentlysemisuccessfullysemisynthesizingsequence␣assemblySexagesima␣Sundayshock␣to␣the␣systemsilvery␣marmosetssingle␣star␣systemSjögren's␣syndromesloppy-mindednessSneddon's␣syndromesnub-nosed␣monkeysspace␣power␣systemspacetime␣physicssuspended␣cymbalssystems␣languagestechnoecosystemstriple␣star␣systemunmysteriousnessvestibular␣systemyucks␣someone's␣yum

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 253 words
  • Spanish Wiktionary: 5 words
  • Italian Wiktionary: no word
  • German Wiktionary: 68 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 42 words

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