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There are 182 sixteen-letter words containing E, 2I and 4S

abscission␣layersaccess␣specifiersambitionlessnessantiprogressistsantischistosomesantiship␣missiles anti-ship␣missilesantisphexishnessAsiatic␣wild␣assesassimilativenessassisted␣suicidesassociative␣casesAustronesianistsboil␣someone's␣pissbrassinosteroidsbusiness␣districtbusinesslikenessbusinessman's␣riskbusinessman's␣tripchemosensitisersChristmas␣diseaseclassical␣studies Classical␣Studiescommissionairessconfessionalisesconfessionalismsconfessionalistsconnoisseurshipsdamsel␣in␣distressdigestive␣systemsdisassembly␣linesdiscoglossideansdisingenuousnessdisjointednessesdispersal␣prisonsdisputatiousnessdissatisfiednessdissertationistsdissimulatressesdivisionlessnessdressing␣stationsecclesiasticismselectric␣bassistsestablished␣suitsfamily␣businessesfinless␣porpoisesfirst␣impressionsfrictionlessnessgousiektebossiesheadmistressship headmistress-shiphostile␣witnessesidentitylessnessillusionlessnessimpermissivenessinaccessiblenessinauspiciousnessinconsistentnessindecisivenessesindigenousnessesindiscreetnessesindissolublenessindistinctnessesinexpressivenessinobsequiousnessinsalubriousnessintermissionlessintussusceptionsirremissiblenessirresistiblenessirresponsivenessisochorismatasesisosbestic␣pointsKawasaki's␣diseasekiss␣someone's␣ringlicentiousnessesLissajous␣figuresloosiest-goosiestmicrosuspensionsmiliary␣abscessesmind␣one's␣businessmisdistinguishesMississippi␣kitesMississippi␣RiverMississippi␣saxesnesidioblastosesnesidioblastosisnonessentialistsnonsensitivenessosphresiologistsossiculoplastiespanel␣discussionsparish␣assembliesparsimoniousnesspassive␣investorsperfidiousnessesphotosensitiserspisses␣like␣a␣horsepissing␣one's␣pantspositionlessnesspossessive␣suffixprincess␣sicknessprocessionalistsprofessionalisesprofessionalismsprofessionalistspromises,␣promisespseudanthessiidspseudoclassicismpseudoscientismspseudoscientistspseudo-socialistspulsus␣bisferiensradiosensitisersreligionlessnessresensitisationsretrocessionistsrhinosinusitisesridiculousnessesrotisserie␣sportsRussian␣dressingssacrilegiousnessSamsonic␣suicidessatisfactionlesssatisfactorinessschismaticalnessschistosomicidessemidiatessaronssemisubmersiblessession␣musicianssessionographiesShakspearianismsshear␣viscositiesSierpinski␣spacessilasesquiazanessilasesquioxanessir,␣this␣is␣a␣Wendy'ssitting␣on␣one's␣asssleeping␣sicknesssocial␣scientistsSpanish␣prisonersspiral␣staircasesspongiosclerosisstereoisomerismssubcommissionerssubdistinguishessubscriptionlesssubset␣classifiersub-superstitionssubversive␣basicssunset␣industriessunset␣provisionssuperciliousnesssuperparasitismssupersessionismssupersessionistssuperspecialistssuperstitionistssuperstitionlesssuppositiousnesssurprise␣surprisesurviving␣spousessuspensibilities

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