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There are 397 sixteen-letter words containing E, I, O, 2P and 2R

(page 3)

reapproximationsred-throated␣pipitrelationshippersrepopularizationreprecipitationsreprographicallyRepublic␣of␣Cyprusretrohippocampalretropropulsionsreverse␣pedophileRobbins␣principlescript␣supervisorsemipornographicSpanish␣prisonersspectrographicalspiropiperidinessportspersonshipspringer␣antelopespur-winged␣ploverstereoplanigraphsupercompetitorssupercompressingsupercompressionsupercorporationsuperencryptionssuperexpressionssuperhydrophilicsuperhydrophobicsupermicroscopicsuperomnipresentsuperpermutationsuperpersonalitysuperprestigioussuperproficiencysuperprominencessuperpromiscuitysuperpromiscuoussuperproportionssuperreplicationsupersuppressionsuppression␣ordertetrasporophyticthree-pipe␣problemtransport␣proteintrembling␣poplarstriarylphosphinetrichloropropanetriphosphorylatetroposphericallytrumpeter␣pigeonsturning␣approversunderapproximate under-approximateunderpreparationunpreponderatingunproportionableupdate␣one's␣priorsuroporphyrinogenvoter␣suppressionwell-proportionedWhipple␣procedure

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