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There are 57 sixteen-letter words containing E, 3O, S and 2U

acropleurogenousautofluorophoresautofluoroscopesavoirdupois␣ouncechondrocutaneouscoconut␣octopusesCoulomb␣repulsiondoubleplusungood double-plus-ungood double-plus␣ungood double␣plus␣ungoodeudicotyledonousfluoroquinolinesfluoroquinolonesgood-humourednessgo␣round␣the␣housesHoughton␣Conquestmonoglucuronidesmuscolotendinousmusculotendonousneuromodulationsnounself␣pronouns noun-self␣pronounsoctulofuranosideoligoguluronatesorthopneumovirusout␣of␣the␣questionoverpopulousnesspolypseudonymouspour␣one's␣heart␣outpour␣out␣one's␣heartpseudocontiguouspseudocontinuouspseudocopulationpseudocopulatorypseudohomologuespseudohomosexualpseudohomozygouspseudomonomerouspseudomorphouslypseudomyxomatouspseudopopulationpseudopseudogoutpseudorevolutionpull␣out␣of␣one's␣assput␣out␣of␣one's␣headput␣out␣of␣one's␣mindquasihomogeneousrun␣roughshod␣oversemiautonomouslysuperhomogeneoussupermacroporoustulostomataceousultrahomogeneouswash␣one's␣mouth␣outwash␣out␣one's␣mouthyou␣snooze␣you␣lose

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