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There are 34 sixteen-letter words containing E, R, 2S, 2T and X

administratrixesanti-heterosexistchitodextrinasesdimethoxystyrylsexistential␣risksExotic␣Shorthairsexperientialistsexperimentalistsextemporisationsexteriorisationsexterminatressesexternalisationsexternal␣stimulusextra␣extra␣smallsextrasolar␣systemextrasyllogisticextrinsicalitiesgross␣receipts␣taxheterosexualistsMarxist-Leninistspostextrasystolerecontextualisessexploitationersshort-tailed␣foxesSix's␣thermometerssixty-fourth␣notessoixante-huitardsSoxhlet␣apparatussuperexcitationssuperextensivitytenor␣saxophonistTexas␣garter␣snaketiller␣extensionstranssexualities

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 173 words
  • Spanish Wiktionary: 5 words
  • Italian Wiktionary: no word
  • German Wiktionary: 29 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 6 words

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