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There are 31 twenty-one-letter words containing 2E, 2M and 3S

adaptive␣immune␣systemsargumentum␣ad␣passionescall␣them␣as␣one␣sees␣themcome␣up␣smelling␣of␣rosescommissions␣de␣bene␣essecompensated␣summationsembarrassment␣of␣richesemphysematous␣cystitisestablishmentarianismEuropean␣Commissionersformiminotransferaseslittle␣summers␣of␣St␣Luke little␣summers␣of␣St.␣Lukemake␣someone's␣skin␣crawlmakes␣someone's␣hair␣curlmaking␣someone's␣ears␣sadMaliseet-Passamaquoddy Maliseet–Passamaquoddymeadow␣grass␣dermatitisMendes␣da␣Costa␣syndromenominative␣type␣systemsoverimmunosuppressionpressure␣makes␣diamondsrefresh␣someone's␣memoryrustle␣someone's␣jim-jamsrustle␣someone's␣jimmiessecond␣impact␣syndromessecond-system␣syndromesswap␣horses␣in␣midstreamwhat␣was␣someone␣smokingyou␣win␣some,␣you␣lose␣some

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