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There are 31 twenty-one-letter words containing 2E, 2M and 3Sadaptive␣immune␣systems argumentum␣ad␣passiones call␣them␣as␣one␣sees␣them come␣up␣smelling␣of␣roses commissions␣de␣bene␣esse compensated␣summations embarrassment␣of␣riches emphysematous␣cystitis establishmentarianism European␣Commissioners formiminotransferases little␣summers␣of␣St␣Luke little␣summers␣of␣St.␣Luke make␣someone's␣skin␣crawl makes␣someone's␣hair␣curl making␣someone's␣ears␣sad Maliseet-Passamaquoddy Maliseet–Passamaquoddy meadow␣grass␣dermatitis Mendes␣da␣Costa␣syndrome nominative␣type␣systems overimmunosuppression pressure␣makes␣diamonds refresh␣someone's␣memory rustle␣someone's␣jim-jams rustle␣someone's␣jimmies second␣impact␣syndromes second-system␣syndromes swap␣horses␣in␣midstream what␣was␣someone␣smoking you␣win␣some,␣you␣lose␣some
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