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There are 580 twenty-one-letter words containing 2E, N, 2O and 2S

abdominohysterotomiesabominable␣snow␣monsterabounds␣in␣one's␣own␣senseabsent-minded␣professorabsolutes␣of␣enfleurageabsorption␣hygrometersadenosinetriphosphate adenosine␣triphosphateadenotonsillectomizesadenylpyrophosphataseadrenocorticosteroidsAlbertine␣sooty␣boubousall␣that␣one's␣life's␣worthanticonfederationistsarithmetic␣progressionarteriovenous␣fistulasas␣if␣there␣is␣no␣tomorrowassistive␣technologiesas␣soon␣as␣look␣at␣someoneattends␣to␣one's␣knittingautonomous␣prefecturesbarking␣dogs␣seldom␣bitebeat␣someone's␣brains␣outbeen␣one's␣own␣worst␣enemybeggars␣can't␣be␣choosersbisbenzylisoquinolinebiting␣someone's␣head␣offbitten␣someone's␣head␣offblack-hooded␣antshrikesblew␣someone's␣brains␣outblow␣someone's␣brains␣outbonfires␣of␣the␣vanitiesBoott's␣rattlesnake␣rootbreaking␣someone's␣ballsbreaking␣someone's␣heartbring␣coals␣to␣NewcastleBruton's␣tyrosine␣kinasebust␣a␣cap␣in␣someone's␣assbutter␣someone's␣biscuitcabinets␣of␣curiositiesCampbell␣de␣Morgan␣spotscarboxamidoadenosinescarry␣coals␣to␣Newcastlecatching␣someone's␣fancycdesign␣proponentsistscell-adhesion␣molecules cell␣adhesion␣moleculescerebral␣localisationscerebrovasculogenesisCharles␣Bonnet␣syndromechemoradiosensitiserschemoradiosensitivitychicken-or-egg␣questions chicken␣or␣egg␣questionsChinese␣postman␣problemchlorodeoxyadenosinescholecystoenterostomycholecystojejunostomychondroskeletogenesiscleaning␣someone's␣clockCocos␣(Keeling)␣Islanderscollar-button␣abscessescollective␣unconsciouscolored␣inside␣the␣linescolors␣outside␣the␣linescolour␣of␣someone's␣moneycolour␣outside␣the␣linescolours␣inside␣the␣linescombat␣stress␣reactionscomes␣up␣with␣the␣rationscome␣up␣smelling␣of␣rosescomfortable␣in␣one's␣skincommissions␣de␣bene␣essecommon␣squirrel␣monkeyscompany␣sergeant␣majorscompany␣sergeants␣majorcompensated␣summationscompensation␣pendulumscompetitive␣exclusionscompliments␣of␣the␣houseconclusive␣presumptioncondensation␣reactionscondensing␣locomotivesconfessional␣debuggingconscientious␣objectorconservative␣extensionconsole␣steel␣guitaristconspiracies␣of␣silenceconstructive␣evictionscontradictionlessnessCopeland-Erdős␣constantcoronary␣artery␣diseasecorticoresponsivenesscould␣not␣have␣cared␣lesscount␣angels␣on␣pinheadscounterdemonstrations counter-demonstrationscounterinvestigationscounterproductivenesscounterreconnaissancecounterrevolutionistscounting␣one's␣blessingscourt␣of␣second␣instancecreatine␣phosphokinasecrooked␣as␣a␣dog's␣hind␣legcross␣the␣t's␣and␣dot␣the␣i'scuriouser␣and␣curiousercurse␣of␣dimensionalitycyclodeoxynucleosides

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