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There are 48 twenty-one-letter words containing E, F, G, L, R and 2S

absolutes␣of␣enfleuragearguments␣from␣illusionarse␣like␣a␣Japanese␣flagbuffalobur␣nightshadesclinging␣to␣the␣skirts␣ofcome␣up␣smelling␣of␣rosesdifferential␣diagnosesdifferential␣diagnosisfirst␣angle␣projectionsFirst␣New␣England␣Schoolfructoligosaccharidesfull␣English␣breakfastsfull␣of␣the␣joys␣of␣springgalactosyltransferasegeneral␣classificationglucanosyltransferaseglucoronyltransferaseglucose-fructose␣syrupsglucuronyltransferasegluttons␣for␣punishmentguest␣relation␣officershyperfibrinogenolysisinferior␣sagittal␣sinusLagunitas-Forest␣Knollslong␣run␣for␣a␣short␣slideMalaysian␣flying␣lemursMaster␣John␣GoodfellowsPersian␣relapsing␣feverpetrol␣filling␣stationsprofessional␣engineersprofessional␣wrestlingpterygomaxillary␣fossapterygopalatine␣fossaereflecting␣microscopesreformulated␣gasolinesself-deserting␣avoidantsemiprofessionalizingsends␣to␣the␣glue␣factorysing␣from␣the␣same␣hymnalsingle␣points␣of␣failuresons␣of␣motherless␣goatssugarcane␣soldier␣fliessurface-supplied␣divingtalking␣someone's␣ear␣offtravelling␣post␣officesvirgin␣fields␣epidemicswhistling␣face␣syndromewrongful␣death␣statutes

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 40 words
  • Spanish Wiktionary: no word
  • Italian Wiktionary: no word
  • German Wiktionary: 183 words
  • Portuguese Wiktionary: 1 word
  • Dutch Wiktionary: 43 words

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