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There are 30 twenty-one-letter words containing E, I, 3M and 2S

adaptive␣immune␣systemsautonomous␣communitiescerebromicroembolismscommitting␣magistratescommon␣squirrel␣monkeyscompensated␣summationsdisembarkment␣syndromedysgammaglobulinemiasempathic␣embarrassmentgammapapillomavirusesIslamic␣fundamentalismlowest␣common␣multiplesmagnetoplasmadynamicsMarxism-Leninism-Maoismmathematical␣semanticsmicrothromboembolismsnon-commissioned␣memberPlummer-Vinson␣syndromeregional␣metamorphismsRevisionist␣Maximalismrubber␣stamp␣committeesrustle␣someone's␣jim-jamsrustle␣someone's␣jimmiesscrambled␣egg␣slime␣moldsemiconductor␣memoriessemigroup␣homomorphismSimmons-Smith␣reactionssimple␣harmonic␣motionssing␣from␣the␣same␣hymnalsystematic␣element␣name

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