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There are 31 twenty-one-letter words containing E, R, 4S and Y

Arndt-Eistert␣synthesisarylsulfotransferasescardiovascular␣systemscentral␣nervous␣systemsEhlers-Danlos␣syndromesendotransglucosylasesendotransglycosidasesendotransglycosylasesenteric␣nervous␣systemsfructosyltransferasesglucose-fructose␣syrupshysterical␣blindnessesit's␣none␣of␣your␣businessKyasanur␣forest␣diseaseLady␣Amherst's␣pheasantslesser␣spot-nosed␣monkeyLyminster␣and␣Crossbushmigratory␣restlessnessmyristoyltransferasesrhamnosyltransferasesRussell-Silver␣syndromescience␣by␣press␣releasesecond-system␣syndromesSilver-Russell␣syndromeSmall␣Business␣SaturdaySouthern␣lady's␣slippersspiny␣softshell␣turtlesstrict-sense␣stationarysyngenesiotransplantssystolic␣blood␣pressurethornless␣honey␣locusts

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 58 words
  • Spanish Wiktionary: no word
  • Italian Wiktionary: no word
  • German Wiktionary: 4 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 11 words

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