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There are 121 twelve-letter words containing I, R, 3S and Y

absciss␣layeracrosyndesisArdois␣systemAssyrianizesAssyriannessastrocytosisastrophysicscross-subsidycryosessionscrystallisescypress␣pinescypress␣vinescystovirusesdays'␣residuesdermanyssidsdisastrouslydistressedlydrebyssosidedressing-boysdysarthrosisdyskeratosisdysmorphismsdysmorphosisdysprosodiasdysprosodiesdyssynergiasembryostasisemissaryshiperysipelasesfairy␣possumsfiery␣crossesfreestylistsgastronyssidgastroxynsisgrissly␣bearshairstylists hair␣stylistshyperaspistshyperosmosishyperostosishystriciasisisoaspartylslyssavirusesmacronyssidsmass␣hysteriaMayo␣scissorsMerseysidersmicrosystemsmyosclerosismyosupressinmystery␣shipsNovorossiyskoysterfishesparasynapsisperissityidsphysiatristsposy-sniffers posy␣snifferspresbyacusispresymbiosisproselytisesproselytismsproselytistspteronyssidspussy␣fingerspussylickersrainy␣seasonsresistlesslyresistotypesresynthesiserhinonyssidsrosh␣yeshivasrowdyishnessrusty␣dustiesRymaszewskisSandy␣Springssarcocystidssatyriasistsscissiparitysecessionarysecretolysissemicrystalssilly␣stringssimple␣syrupssinistrouslysinus␣rhythmssparsistencyspiny␣oystersspiritlesslystepsisterlystrainlesslystreptolysisstromelysinsstrongylosisstylasteridssubmysteriessubway␣seriesSunday␣stripssuperstylishsupply-siderssurpassinglySydneysiders Sydney-siderssympathiserssymposiarchssynarthrosissynchronisessynchronismssynchronistssynonymiserssynthesiserssynthesizerssyrphus␣fliessystematisersystrophiidstranscytosistransmissorytransyctosistribosystemsvisuosensorywhiskey␣sours

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