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There are 214 sixteen-letter words containing 2I and 4S

abscission␣layersaccess␣specifiersacoustic␣bassistsagrarian␣scissorsambitionlessnessantiprogressistsantischistosomesantiship␣missiles anti-ship␣missilesantisphexishnessAsiatic␣wild␣assesassimilationistsassimilativenessassisted␣suicidesassociation␣listsassociative␣casesAustronesianistsbaylisascariasisboil␣someone's␣pissbrassinosteroidsbusiness␣districtbusinesslikenessbusinessman's␣riskbusinessman's␣tripchemosensitisersChristmas␣diseaseclassical␣physicsclassical␣studies Classical␣Studiescommissionairessconfessionalisesconfessionalismsconfessionalistsconnoisseurshipscraniosynostosiscross-subsidisingcross-subsidizingdamsel␣in␣distressdigestive␣systemsdisassembly␣linesdisassimilationsdiscoglossideansdisingenuousnessdisjointednessesdispersal␣prisonsdisputatiousnessdissatisfactionsdissatisfiednessdissertationistsdissimulatressesdivisionlessnessdressing␣stationsecclesiasticismselectric␣bassistsestablished␣suitsfamily␣businessesfinless␣porpoisesfirst␣impressionsfrictionlessnessglass␣transitionsgousiektebossiesgrafting␣scissorsheadmistressship headmistress-shiphostile␣witnessesidentitylessnessillusionlessnessimpermissivenessinaccessiblenessinauspiciousnessinconsistentnessindecisivenessesindigenousnessesindiscreetnessesindissolublenessindistinctnessesinexpressivenessinobsequiousnessinsalubriousnessintermissionlessintussusceptionsirremissiblenessirresistiblenessirresponsivenessisochorismatasesisosbestic␣pointsKawasaki's␣diseasekiss␣someone's␣ringlicentiousnessesLissajous␣figuresloosiest-goosiestmicrosuspensionsmiliary␣abscessesmind␣one's␣businessmisdistinguishesMississippi␣kitesMississippi␣MillsMississippi␣RiverMississippi␣saxesMuddy␣Mississippinesidioblastosesnesidioblastosisnonessentialistsnonsensitivenessopsismodysplasiaosphresiologistsossiculoplastiespanel␣discussionsparish␣assembliesparsimoniousnesspassive␣investorsPatripassianistsperfidiousnessesphotosensitiserspisses␣like␣a␣horsepissing␣one's␣pantspositionlessnesspossessive␣suffixprincess␣sicknessprocessionalistsprofessionalisesprofessionalismsprofessionalistspromises,␣promisespseudanthessiidspseudoclassicismpseudoscientismspseudoscientistspseudo-socialistspsychophysicistspulsus␣bisferiensradiosensitisersreligionlessnessresensitisationsretrocessionistsrhinosinusitisesridiculousnessesrotisserie␣sportsruns␣with␣scissorsRussian␣dressingssacrilegiousnessSamsonic␣suicidesSanskritologistssarcosporidiosissatisfactionlesssatisfactorinessschismaticalnessschistosomicidesscissors␣crossingsemidiatessaronssemisubmersiblessession␣musicianssessionographiesShakspearianismsshear␣viscositiesSierpinski␣spacessilasesquiazanessilasesquioxanessir,␣this␣is␣an␣Arby'ssir,␣this␣is␣a␣Wendy'ssitting␣on␣one's␣asssleeping␣sickness

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