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There are 27 sixteen-letter words containing I, 2L, 2M and 2S

abdominal␣musclescallosumectomiescommon␣crossbillscommonsensicallydissymmetricallyemblematicalnessemblematologistsin␣no␣small␣measurelateral␣meristemsleiomyoblastomasmalassimilationsmechanosensillumMellin␣transformsmicroseismicallyminicellulosomesMississippi␣Millsmonoculturalismsmoral␣relativismsmultilateralismsmultilingualismsmycoplasmologistselenometabolismsemicolonialismssmall␣firm␣effectssmoke-filled␣roomssummation␣pluralsWilliams␣syndrome

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