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There are 397 sixteen-letter words containing I, R, 3S and 2T

(page 3)

subministrationssubstantia␣nigrassubstantive␣verbssubstratomaniacssubstratosphericsub-superstitionssugar␣substitutessums␣of␣their␣partssunset␣industriessupernaturalistssupersaturationssupersensitivitysuperstabilitiessuperstatisticalsuperstitionistssuperstitionlesssupersubstantialsupparasitationssupranaturalistssuprasaturationssurvival␣statutesswearing␣conteststeletransmissiontensile␣strengthsthalassoceratidsthe␣rest␣is␣historythermostatisticsThirsty␣Thursdaysthree-strikes␣lawsthrust␣one's␣nose␣inToronto␣blessingstractionlessnesstranscriptosomesTransdniestrianstransendocytosistransistor␣radiostransitionalnesstransition␣housestransition␣statestransition␣stripstranslative␣casestranslatologiststransmedicaliststransmisogyniststransmissibilitytransmissioniststransmissivitiestransmissometerstranspassivationtransresistancestransresistivitytranssexualitiestranssilylationstransversalitiestransvestigatorstransvestophilestriosephosphates triose␣phosphatestriple␣star␣systemtrisubstitutionstuperssuatsiaitetwist␣someone's␣armultrasonologistsundistractednessuninstructednessuninterestednessunrestrictednessunsystematic␣riskvasoconstrictorsvestibular␣systemvirtual␣assistantwhistle␣registerswhistlestop␣tourswhite␣Christmaseswrit␣of␣assistance

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