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There are 59 twenty-one-letter words containing I, 2O, 3S and Y

ankylosing␣spondylitisasteroseismologicallyBruton's␣tyrosine␣kinaseclassification␣societycriminal␣psychologistscystofilobasidiaceousdesoxyribonucleosidesdysgranulocytopoiesisdyskeratosis␣congenitaendotransglycosidasesexplosive␣cyclogenesesexplosive␣cyclogenesisgalactosylsphingosineglucosylcerebrosidaseglycophosphoinositolsglycosphingolipidosisglycosylsphingolipidsgyroscopic␣stabilizersHashimoto's␣thyroiditisheads␣I␣win,␣tails␣you␣loseHis␣Majesty's␣Oppositionit's␣none␣of␣your␣businessleucoerythroblastosisleukoerythroblastosislysophosphoglyceridesmucopolysaccharidasesmucopolysaccharidosesmucopolysaccharidosisneuropsychotherapistsoak␣processionary␣mothsobsessive-compulsivityosteochondrodysplasiaosteochondrodysplasicpachydermoperiostosisParkinson-plus␣syndromephosphatidylinositolsphosphoribohydrolasesphotoelectrosynthesisphysiologic␣dead␣spacesplay␣into␣someone's␣handspolyphosphoinositidespolysialogangliosidespostperfusion␣syndromepsychopharmacologistspsychotraumatologistsRadishes␣and␣Gooseberryreticulohistiocytosesreticulohistiocytosissecond␣impact␣syndromesshallow␣brooks␣are␣noisysphenomaxillary␣fossaesteal␣someone's␣identitystole␣someone's␣identitystriking␣someone's␣fancysystolic␣blood␣pressuretransgalactosylationstransphosphorylationsYorkshire␣assimilationyou␣win␣some,␣you␣lose␣some

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 99 words
  • Spanish Wiktionary: no word
  • Italian Wiktionary: no word
  • German Wiktionary: 3 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 6 words

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