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There are 62 twenty-one-letter words containing L, 2O, 3S and Y

ankylosing␣spondylitisasteroseismologicallycholecystogastrostomyclassification␣societycriminal␣psychologistscystofilobasidiaceousdesoxyribonucleosidesdysgranulocytopoiesisEhlers-Danlos␣syndromesendotransglucosylasesendotransglycosidasesendotransglycosylaseserythrophagolysosomesexplosive␣cyclogenesesexplosive␣cyclogenesisgalactosylsphingosineglucose-fructose␣syrupsglucosylcerebrosidaseglycophosphoinositolsglycosphingolipidosisglycosylsphingolipidsgyroscopic␣stabilizersheads␣I␣win,␣tails␣you␣loselesser␣spot-nosed␣monkeyleucoerythroblastosisleukoerythroblastosislysophosphoglyceridesmaster␣of␣all␣one␣surveysmucopolysaccharidasesmucopolysaccharidosesmucopolysaccharidosisobsessive-compulsivityosteochondrodysplasiaosteochondrodysplasicParkinson-plus␣syndromephosphatidylinositolsphosphoglyceromutasesphosphoribohydrolasesphosphoryltransferasephosphotransacetylasephotoelectrosynthesisphysiologic␣dead␣spacesplay␣into␣someone's␣handsplease␣speak␣more␣slowlypolyphosphoinositidespolysialogangliosidespostzygosynapophysealpsychopharmacologistspsychotraumatologistspyrophosphohydrolasesreticulohistiocytosesreticulohistiocytosisshallow␣brooks␣are␣noisysphenomaxillary␣fossaesteal␣someone's␣identitystole␣someone's␣identitysystolic␣blood␣pressurethornless␣honey␣locuststransgalactosylationstransphosphorylationsYorkshire␣assimilationyou␣win␣some,␣you␣lose␣some

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 74 words
  • Spanish Wiktionary: no word
  • Italian Wiktionary: no word
  • German Wiktionary: 3 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 6 words

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