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There are 167 twenty-letter words containing 2O, P, R, 2S and Y

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Sapir-Whorf␣hypothesissecond␣impact␣syndromeseparable␣polynomialssialoglycoproteomicssocial␣responsibilitysphenomaxillary␣fossaspondylarthropathiesspondylotherapeuticsspotless␣grass␣yellowsstereospondylomorphssuperiority␣complexessupraphysiologicallysymmetric␣polynomialssymplesiomorphicallysynchronisation␣proxysyncytiotrophoblaststhioglucopyranosidesthiophosphorylationsthird␣party␣processorstransphosphorylatingtransphosphorylationtransport␣safety␣boardtriphosphohydrolasestrispyrazolylboratesturnip-rooted␣parsleystychoparthenogenesisuniversity␣professorsureterocystoplastiesvagoglossopharyngealvery␣important␣personswhite␣cheese␣polyporesyellow-crowned␣bishops

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 148 words
  • Spanish Wiktionary: no word
  • Italian Wiktionary: no word
  • German Wiktionary: 12 words
  • Portuguese Wiktionary: no word
  • Dutch Wiktionary: 4 words

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