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There are 60 twenty-one-letter words containing O, P, R, 2S and 2U

argumentum␣ad␣passionesauriculares␣superioresautonomous␣prefecturesbutterflies␣upon␣wheelscasualty␣of␣superiorityChannel-Port␣aux␣Basquesconclusive␣presumptioncounterproductivenessequipotential␣surfacesglucose-fructose␣syrupsgluttons␣for␣punishmentGuadalupe␣storm␣petrelshigh-fructose␣corn␣syrup high␣fructose␣corn␣syruphuman␣papillomaviruseshydrodesulphurisationjugular␣venous␣pressurejump␣before␣one␣is␣pushedmalicious␣prosecutionsmetal␣cluster␣compoundsnitrosylsulphuric␣acidnoun␣substantive␣properoverimmunosuppressionpast␣perfect␣continuouspercussion␣instrumentspressure␣volume␣diagrampropositional␣calculuspseudopharmaceuticalspseudorevolutionariespseudosclerodermatouspulmonary␣tuberculosispunctus␣interrogativuspushed␣the␣right␣buttonspushes␣the␣right␣buttonsputs␣a␣bug␣in␣someone's␣earputs␣butter␣on␣one's␣breadquantum␣processing␣unitrequests␣for␣productionrufous-capped␣antshrikerufous-collared␣sparrowSan␣Pedro␣Amuzgos␣Amuzgosarcoplasmic␣reticulumspatulasnout␣catsharksspinal␣muscular␣atrophysupercompound␣interest super-compound␣interestsupergranulation␣cellssuperior␣oblique␣musclesuperior␣petrosal␣sinussuperior␣sagittal␣sinussupernatural␣selectionsupernumerary␣rainbowsSuperstition␣Mountainssurplus␣to␣requirementsteardrop␣tubeshouldersuniversal␣product␣codeswestern␣spruce␣budwormswork␣best␣under␣pressurework␣well␣under␣pressureyou␣must␣be␣fun␣at␣parties

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See this list for:

  • Scrabble in English: no word
  • French Wiktionary: 181 words
  • Spanish Wiktionary: 4 words
  • Italian Wiktionary: no word
  • German Wiktionary: 43 words
  • Portuguese Wiktionary: 1 word
  • Dutch Wiktionary: 17 words

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